Article
Silencer-mediated repression and non-mediated activation of BDNF and c-fos gene promoters in primary glial or neuronal cells.
Biochemical and biophysical research communications - 2 Aug 1999
Tabuchi A, Nakatani C, Nakaoka R, Naruse Y, Kojima T, Mori N, Tsuda M
Abstract excerpt
Although the neuron-restrictive silencer element (NRSE/Regard) has been shown to function as a negative-acting DNA regulatory element to prevent the expression of neuron-specific genes in non-neuronal cells, little is known about its silencing effect on transcription in primary glial cells nor its effect on transcriptional activation in primary neurons. By DNA transfection in primary cultures of rat cortical...
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