Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relaxation of glycine receptor and onconeural gene transcription control in NRSF deficient small cell lung cancer cell lines.

Brain research. Molecular brain research - 5 Jan 2004

Neumann Sabine B, Seitz Randolf, Gorzella Anke, Heister Angelien, Doeberitz Magnus von Knebel, Becker Cord Michael

Abstract excerpt

Negative regulation of many neuronal genes is mediated by the neuron-restrictive silencer factor (NRSF/repressor element-1 binding transcription factor, REST), which binds to the neuron-restrictive silencer element (NRSE/repressor element-1, RE-1) and thereby represses transcription of neuronal genes in non-neuronal cells. Sequence analysis of 5'-flanking regions of glycine receptor (GlyR) subunit genes revealed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Carcinoma, Small Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Recombinant

Share to Genes, Reporter

Share to Lymphocytes

Share to Protein Subunits

Share to Receptors, Glycine

Share to Repressor Proteins

Source

Identifiers

PMID: 14741407
DOI: 10.1016/j.molbrainres.2003.10.021

Genes

REST
GLRA1
GLRA3
GLRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relaxation of glycine receptor and onconeural gene transcription control in NRSF deficient small cell lung cancer cell lines.PMID 14741407Read ↗

A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker.Semantic proximity Read ↗

Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells.Semantic proximity Read ↗

Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer.Semantic proximity Read ↗

NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray studySemantic proximity Read ↗

Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines.Semantic proximity Read ↗

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis.Semantic proximity Read ↗

Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes.Semantic proximity Read ↗

RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate CancerSemantic proximity Read ↗

Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.Semantic proximity Read ↗

Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.Semantic proximity Read ↗

Mechanism of Retinoblastoma Gene Inactivation in the Spectrum of Neuroendocrine Lung TumorsSemantic proximity Read ↗

SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.