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Article

A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.

Blood - 1 Dec 2011

Juchem Kathryn W, Anderson Britt E, Zhang Cuiling, McNiff Jennifer M, Demetris Anthony J, Farber Donna L, Caton Andrew J, Shlomchik Warren D, Shlomchik Mark J

Abstract excerpt

Effector memory T cells (T(EM)) do not cause graft-versus-host disease (GVHD), though why this is has not been elucidated. To compare the fates of alloreactive naive (T(N)) or memory (T(M)) T cells, we developed a model of GVHD in which donor T cells express a transgene-encoded TCR specific for an antigenic peptide that is ubiquitously expressed in the recipient. Small numbers of naive TCR transgenic (Tg) T cells...

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Identifiers

PMID: 21768295
DOI: 10.1182/blood-2011-01-330035
PMCID: PMC3234673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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