Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.

doi:10.1073/pnas.96.10.5510

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Article

Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.

Proceedings of the National Academy of Sciences of the United States of America - 11 May 1999

Liakopoulos D, Büsgen T, Brychzy A, Jentsch S, Pause A

Abstract excerpt

The von Hippel-Lindau tumor suppressor protein pVHL assembles with cullin-2 (hCUL-2) and elongin B/C forming a protein complex, CBCVHL, that resembles SKP1-CDC53-F-box protein ubiquitin ligases. Here, we show that hCUL-2 is modified by the conserved ubiquitin-like protein NEDD8 and that NEDD8-hCUL-2 conjugates are part of CBCVHL complexes in vivo. Remarkably, the formation of these conjugates is stimulated by the...

Topics

Carrier Proteins
Cell Cycle Proteins
Cell Line
Cell Survival
Cullin Proteins
Fungal Proteins
Humans
Ligases
Mutation
NEDD8 Protein
Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

Saccharomyces cerevisiae Proteins

Suppression, Genetic

Temperature

Transfection

Tumor Suppressor Proteins

Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 10318914
DOI: 10.1073/pnas.96.10.5510
PMCID: PMC21890

Genes

NEDD8
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.PMID 10318914Read ↗

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.Semantic proximity Read ↗

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteinsSemantic proximity Read ↗

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