Article
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 1999
Iwai K, Yamanaka K, Kamura T, Minato N, Conaway R C, Conaway J W, Klausner R D, Pause A
Abstract excerpt
Mutations of von Hippel-Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited VHL syndrome and in the vast majority of sporadic clear cell renal carcinomas. The function of the pVHL protein has not been clarified. pVHL has been shown to form a complex with elongin B and elongin C (VBC) and with cullin (CUL)-2. In light of the structural analogy of VBC-CUL-2 to...
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