Article
Activation of human herpesvirus 8 (HHV-8) thymidine kinase (TK) TATAA-less promoter by HHV-8 ORF50 gene product is SP1 dependent.
DNA and cell biology - 1 Sept 1998
Zhang L, Chiu J, Lin J C
Abstract excerpt
Human herpesvirus 8 (HHV-8) is a newly discovered virus closely associated with Kaposi's sarcoma and primary effusion lymphomas. When they occur in patients with AIDS, these B-cell lymphomas frequently harbor another human herpesvirus, Epstein-Barr virus (EBV). To determine the molecular mechanis...
Topics
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA, Viral
- Genes, Immediate-Early
- Herpesvirus 4, Human
- Herpesvirus 8, Human
- Humans
- Immediate-Early Proteins
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Protein Binding
- Recombinant Fusion Proteins
- Sp1 Transcription Factor
- Tetradecanoylphorbol Acetate
- Thymidine Kinase
- Trans-Activators