Mechanisms of genome-wide hypermutation in stationary phase.

doi:10.1111/j.1749-6632.1999.tb08888.x

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Article

Mechanisms of genome-wide hypermutation in stationary phase.

Annals of the New York Academy of Sciences - 18 May 1999

Lombardo M J, Torkelson J, Bull H J, McKenzie G J, Rosenberg S M

Abstract excerpt

Stationary-phase mutation (a subset of which was previously called adaptive mutation) occurs in apparently nondividing, stationary-phase cells exposed to a nonlethal genetic selection. In one experimental system, stationary-phase reversion of an Escherichia coli F'-borne lac frameshift mutation occurs by a novel molecular mechanism that requires homologous recombination functions of the RecBCD system. Chromosomal...

Topics

DNA Repair
DNA-Directed DNA Polymerase
Escherichia coli
Exodeoxyribonuclease V
Exodeoxyribonucleases
Genome, Bacterial
Models, Genetic
Mutation
Recombination, Genetic

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Identifiers

PMID: 10415490
DOI: 10.1111/j.1749-6632.1999.tb08888.x

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