Article
The role of transient hypermutators in adaptive mutation in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 1999
Rosche W A, Foster P L
Abstract excerpt
Microbial populations under nonlethal selection can give rise to mutations that relieve the selective pressure, a phenomenon that has come to be called "adaptive mutation." One explanation for adaptive mutation is that a small proportion of the cells experience a period of transient hypermutation, and that these hypermutators account for the mutations that appear. The experiments reported here investigated the...
Topics
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Genome, Bacterial
- Lac Operon
- Mutation