Article
Minimal essential domains specifying toxicity of the light chains of tetanus toxin and botulinum neurotoxin type A.
The Journal of biological chemistry - 25 Jul 1992
Kurazono H, Mochida S, Binz T, Eisel U, Quanz M, Grebenstein O, Wernars K, Poulain B, Tauc L, Niemann H
Abstract excerpt
To define conserved domains within the light (L) chains of clostridial neurotoxins, we determined the sequence of botulinum neurotoxin type B (BoNT/B) and aligned it with those of tetanus toxin (TeTx) and BoNT/A, BoNT/C1, BoNT/D, and BoNT/E. The L chains of BoNT/B and TeTx share 51.6% identical a...
Topics
- Acetylcholine
- Amino Acid Sequence
- Animals
- Aplysia
- Base Sequence
- Botulinum Toxins
- Depression, Chemical
- Genetic Vectors
- Microinjections
- Molecular Sequence Data
- Mutation
- Protein Biosynthesis
- RNA, Messenger
- Sequence Alignment
- Tetanus Toxin
- Transcription, Genetic
- Xenopus