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Article

A mitochondrial pyruvate dehydrogenase bypass in the yeast Saccharomyces cerevisiae.

The Journal of biological chemistry - 23 Jul 1999

Boubekeur S, Bunoust O, Camougrand N, Castroviejo M, Rigoulet M, Guérin B

Abstract excerpt

Spheroplasts of the yeast Saccharomyces cerevisiae oxidize pyruvate at a high respiratory rate, whereas isolated mitochondria do not unless malate is added. We show that a cytosolic factor, pyruvate decarboxylase, is required for the non-malate-dependent oxidation of pyruvate by mitochondria. In pyruvate decarboxylase-negative mutants, the oxidation of pyruvate by permeabilized spheroplasts was abolished. In...

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PMID: 10409655
DOI: 10.1074/jbc.274.30.21044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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