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The effect of pyruvate decarboxylase gene knockout in Saccharomyces cerevisiae on L-lactic acid production.

Bioscience, biotechnology, and biochemistry - 1 May 2006

Ishida Nobuhiro, Saitoh Satoshi, Onishi Toru, Tokuhiro Kenro, Nagamori Eiji, Kitamoto Katsuhiko, Takahashi Haruo

Abstract excerpt

A plant- and crop-based renewable plastic, poly-lactic acid (PLA), is receiving attention as a new material for a sustainable society in place of petroleum-based plastics. We constructed a metabolically engineered Saccharomyces cerevisiae that has both pyruvate decarboxylase genes (PDC1 and PDC5) disrupted in the genetic background to express two copies of the bovine L-lactate dehydrogenase (LDH) gene. With this...

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PMID: 16717415
DOI: 10.1271/bbb.70.1148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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