Article
Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast.
The Journal of biological chemistry - 2 Sept 2005
Schwimmer Christine, Lefebvre-Legendre Linnka, Rak Malgorzata, Devin Anne, Slonimski Piotr P, di Rago Jean-Paul, Rigoulet Michel
Abstract excerpt
In a previous study we have identified Fmc1p, a mitochondrial protein involved in the assembly/stability of the yeast F0F1-ATP synthase at elevated temperatures. The deltafmc1 mutant was shown to exhibit a severe phenotype of very slow growth on respiratory substrates at 37 degrees C. We have isolated ODC1 as a multicopy suppressor of the fmc1 deletion restoring a good respiratory growth. Odc1p expression level...
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