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Article

Characterization of Saccharomyces cerevisiae mutants lacking the E1 alpha subunit of the pyruvate dehydrogenase complex.

European journal of biochemistry - 15 Oct 1992

Wenzel T J, van den Berg M A, Visser W, van den Berg J A, Steensma H Y

Abstract excerpt

Pyruvate dehydrogenase mutants of Saccharomyces cerevisiae were isolated by disruption of the PDA1 gene. To this end, the PDA1 gene encoding the E1 alpha subunit of the pyruvate dehydrogenase complex was replaced by the dominant Tn5ble marker. Disruption of the PDA1 gene abolished production of the E1 alpha subunit and pyruvate dehydrogenase activity. Two additional phenotypes were observed in the Pdh-mutants:...

Topics

DNA Transposable Elements
DNA, Mitochondrial
Genes, Fungal
Genetic Complementation Test
Genotype
Macromolecular Substances
Mutagenesis, Insertional
Plasmids
Pyruvate Dehydrogenase Complex
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rho Factor

Saccharomyces cerevisiae

Source

Identifiers

PMID: 1330555
DOI: 10.1111/j.1432-1033.1992.tb17338.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1330555-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of Saccharomyces cerevisiae mutants lacking the E1 alpha subunit of the pyruvate dehydrogenase complex.PMID 1330555Read ↗

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