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Article

Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations.

Molecular biology of the cell - 1 Mar 2018

Caneus Julbert, Granic Antoneta, Rademakers Rosa, Dickson Dennis W, Coughlan Christina M, Chial Heidi J, Potter Huntington

Abstract excerpt

Mutant Tau (MAPT) can lead to frontotemporal lobar degeneration (FTLD). Previous studies associated MAPT mutations and altered function with aneuploidy and chromosome instability in human lymphocytes and in Drosophila development. Here we examine whether FTLD-causing mutations in human MAPT induce aneuploidy and apoptosis in the mammalian brain. First, aneuploidy was found in brain cells from MAPT mutant...

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Identifiers

PMID: 29282277
DOI: 10.1091/mbc.E17-01-0031
PMCID: PMC6004587

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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