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Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease

29 Nov 2007

Abstract excerpt

Alzheimer's disease (AD) is a premature ageing syndrome characterized by cognitive impairment arising from neuropathological changes occurring within specific areas of the brain. We report a 1.5-fold increase in trisomy 21 (P < 0.001) and a 1.2-fold increase in trisomy 17 (P < 0.001) in buccal cells of Alzheimer's patients compared to age- and gender-matched controls. Chromosome 17 and chromosome 21 monosomy and...

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PMID: 18048581
DOI: 10.1093/mutage/gem044

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