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Article

Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease

7 Dec 2015

Abstract excerpt

Trisomy 21 and the consequent extra copy of the amyloid precursor protein (APP) gene and increased beta-amyloid (Aβ) peptide production underlie the universal development of Alzheimer's disease (AD) pathology and high risk of AD dementia in people with Down syndrome (DS). Trisomy 21 and other forms of aneuploidy also arise among neurons and peripheral cells in both sporadic and familial AD and in mouse and cell...

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PMID: 26651340
DOI: 10.2174/156720501301151207100616

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