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Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening

23 Jun 1999

Abstract excerpt

Telomere shortening during human aging has been reported to be accelerated by oxidative stress. We investigated the mechanism of telomere shortening by oxidative stress. H2O2 plus Cu(II) caused predominant DNA damage at the 5' site of 5'-GGG-3' in the telomere sequence. Furthermore, H2O2 plus Cu(II) induced 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) formation in telomere sequences more efficiently than that in...

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Share to DNA Repair Mechanisms
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PMID: 10405177
DOI: 10.1016/s0014-5793(99)00748-6

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