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Article

Site-Specific DNA Damage at the GGG Sequence by UVA Involves Acceleration of Telomere Shortening

23 Mar 2001

Abstract excerpt

Telomere shortening is associated with cellular senescence. We investigated whether UVA, which contributes to photoaging, accelerates telomere shortening in human cultured cells. The terminal restriction fragment (TRF) from WI-38 fibroblasts irradiated with UVA (365-nm light) decreased with increasing irradiation dose. Furthermore, UVA irradiation dose-dependently increased the formation of...

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Share to Circadian rhythm and melatonin
Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 11294644
DOI: 10.1021/bi002721g

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