Article
Incidence and clinical consequences of surface and polymerase gene mutations in liver transplant recipients on hepatitis B immunoglobulin.
Hepatology (Baltimore, Md.) - 1 Aug 1998
Terrault N A, Zhou S, McCory R W, Pruett T L, Lake J R, Roberts J P, Ascher N L, Wright T L
Abstract excerpt
Mutations in the "a" determinant of the surface gene have been associated with failure of hepatitis B immunoglobulin (HBIg) prophylaxis. We compared sequences from the surface and polymerase regions of hepatitis B virus (HBV) from 4 patients who failed high-dose HBIg therapy with two control groups: HBIg-treated patients who remained hepatitis B surface antigen (HBsAg)-negative (n = 4) and HBV-infected transplant...
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