Article
Incidence and clinical consequences of surface and polymerase gene mutations in liver transplant recipients on hepatitis B immunoglobulin.
Hepatology (Baltimore, Md.) - 1 Aug 1998
Terrault N A, Zhou S, McCory R W, Pruett T L, Lake J R, Roberts J P, Ascher N L, Wright T L
Abstract excerpt
Mutations in the "a" determinant of the surface gene have been associated with failure of hepatitis B immunoglobulin (HBIg) prophylaxis. We compared sequences from the surface and polymerase regions of hepatitis B virus (HBV) from 4 patients who failed high-dose HBIg therapy with two control grou...
Topics
- Adult
- DNA-Directed DNA Polymerase
- Female
- Hepatitis B Surface Antigens
- Humans
- Immunization, Passive
- Immunoglobulins
- Liver Transplantation
- Male
- Middle Aged
- Mutation
- Recurrence
- Time Factors