Article
Hepatitis B virus envelope variation after transplantation with and without hepatitis B immune globulin prophylaxis.
Hepatology (Baltimore, Md.) - 1 Sept 1996
Carman W F, Trautwein C, van Deursen F J, Colman K, Dornan E, McIntyre G, Waters J, Kliem V, Müller R, Thomas H C, Manns M P
Abstract excerpt
Hepatitis B virus (HBV) replicates via an intermediate RNA step. High frequency of polymerase errors with additional selection pressure leads to mutations in the HBV genome. We investigated the number, type, and antigenic effects of mutations in the coding region of the HBV surface antigen in eig...
Topics
- Amino Acid Sequence
- Base Sequence
- Epitopes
- Genetic Variation
- Genome, Viral
- Hepatitis B
- Hepatitis B e Antigens
- Humans
- Immunization, Passive
- Immunoglobulins
- Immunosuppression Therapy
- Liver Transplantation
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction