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Article

Deletion in HCDR3 rescues T15 antibody mutants from a secretion defect caused by mutations in HCDR2.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1996

Martin T M, Kowalczyk C, Stevens S, Wiens G D, Stenzel-Poore M P, Rittenberg M B

Abstract excerpt

We recently described mutants of the murine anti-phosphocholine Ab T15, with changes in heavy chain complementarity determining region 2 (HCDR2) that caused loss of secretion. Surprisingly, the T15 HCDR2 mutations did not alter secretion when placed into the related anti-phosphocholine Ab D16, which differs from T15 only in HCDR3 and light (L) chain. Here, we exploit the differences between these two Abs to...

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Source

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PMID: 8906808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Deletion in HCDR3 rescues T15 antibody mutants from a secretion defect caused by mutations in HCDR2.PMID 8906808Read ↗

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