Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endogenous insulin-like growth factors regulate the proliferation of TSH-independent mutants derived from FRTL5 cells.

Biochimie - 1 Apr 1999

Chieffi P, Picascia A, Stanzione R, Villone G, Tramontano D

Abstract excerpt

TSH-independent mutant clones (M cells) derived from FRTL5 cells, proliferate vigorously in the absence of TSH. The growth of M cells is stimulated by IGF-I in a dose-dependent fashion, but it is not influenced by TSH. Sm1.2, an antibody against IGF-I cross-reacting with IGF-II, significantly decreases basal DNA synthesis in the M cells. Binding of 125I-IGF-I to M cells is significantly lower than that to FRTL5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to Cell Division
Share to Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor II

Share to Mitogens

Share to Receptor, IGF Type 1

Share to Thyroid Gland

Share to Thyrotropin

Source

Identifiers

PMID: 10401671
DOI: 10.1016/s0300-9084(99)80083-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Endogenous insulin-like growth factors regulate the proliferation of TSH-independent mutants derived from FRTL5 cells.PMID 10401671Read ↗

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.Semantic proximity Read ↗

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.Semantic proximity Read ↗

Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.Semantic proximity Read ↗

Dissociation of thyrotropin receptor function and thyrotropin dependency in rat thyroid tumour cell lines derived from FRTL-5.Semantic proximity Read ↗

Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor.Semantic proximity Read ↗

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.Semantic proximity Read ↗

Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells.Semantic proximity Read ↗

Mutant cell line demonstrating a block in insulin and insulin-like growth factor type 1 (IGF-1) induced mitogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.