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Article

Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel.

The Journal of general physiology - 1 Jul 1999

Morrill J A, MacKinnon R

Abstract excerpt

The pore of the catfish olfactory cyclic nucleotide-gated (CNG) channel contains four conserved glutamate residues, one from each subunit, that form a high-affinity binding site for extracellular divalent cations. Previous work showed that these residues form two independent and equivalent high-pKa (approximately 7.6) proton binding sites, giving rise to three pH-dependent conductance states, and it was suggested...

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Identifiers

PMID: 10398693
DOI: 10.1085/jgp.114.1.71
PMCID: PMC2229637

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Source receipt: pubmed, retrieved 7 Sept 2026.

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