Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes.

Journal of autoimmunity - 1 Aug 1995

Pettersson A, Wilson D, Daniels T, Tobin S, Jacob H J, Lander E S, Lernmark A

Abstract excerpt

The spontaneously diabetic BB rat is an excellent and well studied model for human insulin-dependent diabetes (IDDM), sharing many important features with the human disease. Similarities include an equal frequency of IDDM in males and females, production of antibodies against pancreatic cell antigens, and an MHC disease association. In addition, the BB rat shares with human IDDM patients an increased frequency of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Disease Susceptibility

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Risk Factors

Source

Identifiers

PMID: 7492346
DOI: 10.1016/0896-8411(95)90004-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes.PMID 7492346Read ↗

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.Semantic proximity Read ↗

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.Semantic proximity Read ↗

Thymic epithelial defects and predisposition to autoimmune disease in BB rats.Semantic proximity Read ↗

Type 1 Diabetes in the BB Rat: A Polygenic DiseaseSemantic proximity Read ↗

BB rat <i>lyp</i> mutation and Type 1 diabetesSemantic proximity Read ↗

Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility.Semantic proximity Read ↗

Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.Semantic proximity Read ↗

BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2.Semantic proximity Read ↗

Genetic dissection of autoimmune type I diabetes in the BB ratSemantic proximity Read ↗

Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.Semantic proximity Read ↗

The lymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes.Semantic proximity Read ↗

Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.