Beta 2-microglobulin gene is mutated in a human colon cancer cell line (HCT) deficient in the expression of HLA class I antigens on the cell surface.

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Article

Beta 2-microglobulin gene is mutated in a human colon cancer cell line (HCT) deficient in the expression of HLA class I antigens on the cell surface.

Cancer research - 1 Mar 1992

Gattoni-Celli S, Kirsch K, Timpane R, Isselbacher K J

Abstract excerpt

The human colon cancer cell line HCT does not express any detectable HLA class I antigens on the cell surface. RNA blot analyses showed that HCT cells synthesize easily detectable levels of heavy chains as well as beta 2-microglobulin (beta 2m) transcripts. Experiments of immunoprecipitation reve...

Topics

Base Sequence
Colonic Neoplasms
DNA
Histocompatibility Antigens Class I
Humans
Immunoglobulin Heavy Chains
Molecular Sequence Data
Mutation
Precipitin Tests
Tumor Cells, Cultured
beta 2-Microglobulin

Source

Open in PubMed

Identifiers

PMID: 1737380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1737380-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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