Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation

1 Feb 1999

Abstract excerpt

Overexpression of transcription factor AP-2 has been implicated in the tumorigenicity of the human teratocarcinoma cell lines PA-1 that contain an activated ras oncogene. Here we show evidence that overexpression of AP-2 sequesters transcriptional coactivators which results in self-inhibition. We identified AP-2-interacting proteins and determined whether these proteins were coactivators for AP-2-mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium signaling and nucleotide metabolism
Share to PARP inhibition in cancer therapy
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9889285
DOI: 10.1093/nar/27.3.866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activationPMID 9889285Read ↗

PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation.Semantic proximity Read ↗

Aberrant expressions of AP-2α splice variants in pancreatic cancer.Semantic proximity Read ↗

AP-2 enhances Sp1-dependent activation of the growth-regulated human ATP/ADP translocator.Semantic proximity Read ↗

Functional interaction between human papillomavirus type 18 E2 and poly(ADP-ribose) polymerase 1.Semantic proximity Read ↗

Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene.Semantic proximity Read ↗

Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression.Semantic proximity Read ↗

Beyond PARP1: The Potential of Other Members of the Poly (ADP-Ribose) Polymerase Family in DNA Repair and Cancer TherapeuticsSemantic proximity Read ↗

The <scp>PARP</scp> family: insights into functional aspects of poly ( <scp>ADP</scp> ‐ribose) polymerase‐1 in cell growth and survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.