Article
Distinct patterns of protein binding to the MAT2A promoter in normal and leukemic T cells.
Biochimica et biophysica acta - 25 Jul 2001
Halim A B, LeGros H L, Chamberlin M E, Geller A, Kotb M
Abstract excerpt
The metabolism of S-adenosylmethionine (AdoMet), a key molecule in regulating T cell differentiation and proliferation, is different in normal and leukemic T cells. To delineate the basis for these differences we studied the transcriptional regulation of human methionine adenosyltransferase II (MAT II), which catalyzes AdoMet synthesis in these cells. Recently, we identified an Sp1 site in the proximal promoter...
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