Article
The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing.
The Journal of biological chemistry - 3 Oct 1997
Heinemeyer W, Fischer M, Krimmer T, Stachon U, Wolf D H
Abstract excerpt
The 26 S proteasome is the central protease involved in ubiquitin-mediated protein degradation and fulfills vital regulatory functions in eukaryotes. The proteolytic core of the complex is the 20 S proteasome, a cylindrical particle with two outer rings each made of 7 different alpha-type subunit...
Topics
- Amino Acid Sequence
- Animals
- Archaea
- Binding Sites
- Chymotrypsin
- Cysteine Endopeptidases
- DNA Mutational Analysis
- DNA Primers
- Enzyme Precursors
- Gene Deletion
- Genotype
- Macromolecular Substances
- Mammals
- Models, Structural
- Molecular Sequence Data
- Multienzyme Complexes
- Mutagenesis, Site-Directed
- Polymerase Chain Reaction