Autocatalytic processing of the 20S proteasome.

doi:10.1038/382468a0

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Article

Autocatalytic processing of the 20S proteasome.

Nature - 1 Aug 1996

Seemuller E, Lupas A, Baumeister W

Abstract excerpt

The Ntn (N-terminal nucleophile) hydrolases are enzymes with an unusual four-layer alpha + beta fold. The amino-terminal residue (cysteine, serine or threonine) of the mature protein is the catalytic nucleophile, and its side chain is activated for nucleophilic attack by transfer of its proton to...

Topics

Amino Acid Sequence
Catalysis
Cloning, Molecular
Conserved Sequence
Cysteine Endopeptidases
Humans
Molecular Sequence Data
Multienzyme Complexes
Mutation
Proteasome Endopeptidase Complex
Protein Processing, Post-Translational
Sequence Homology, Amino Acid
Thermoplasma

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