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Article

Autocatalytic processing of the 20S proteasome.

Nature - 1 Aug 1996

Seemuller E, Lupas A, Baumeister W

Abstract excerpt

The Ntn (N-terminal nucleophile) hydrolases are enzymes with an unusual four-layer alpha + beta fold. The amino-terminal residue (cysteine, serine or threonine) of the mature protein is the catalytic nucleophile, and its side chain is activated for nucleophilic attack by transfer of its proton to the free N terminus, although other active-site residues may also be involved. The four currently known Ntn hydrolases...

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Identifiers

PMID: 8684489
DOI: 10.1038/382468a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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