Article
Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activation.
Molecular and cellular biology - 1 Jan 2000
Shima F, Okada T, Kido M, Sen H, Tanaka Y, Tamada M, Hu C D, Yamawaki-Kataoka Y, Kariya K, Kataoka T
Abstract excerpt
Posttranslational modification, in particular farnesylation, of Ras is crucial for activation of Saccharomyces cerevisiae adenylyl cyclase (CYR1). Based on the previous observation that association of CYR1 with cyclase-associated protein (CAP) is essential for its activation by posttranslationally modified Ras, we postulated that the associated CAP might contribute to the formation of a Ras-binding site of CYR1,...
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