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Article

Substitution rate variation among sites in mitochondrial hypervariable region I of humans and chimpanzees.

Molecular biology and evolution - 1 Oct 1999

Excoffier L, Yang Z

Abstract excerpt

Mitochondrial D-loop hypervariable region I (HVI) sequences are widely used in human molecular evolutionary studies, and therefore accurate assessment of rate heterogeneity among sites is essential. We used the maximum-likelihood method to estimate the gamma shape parameter alpha for variable substitution rates among sites for HVI from humans and chimpanzees to provide estimates for future studies. The complete...

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PMID: 10563016
DOI: 10.1093/oxfordjournals.molbev.a026046

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