Article
Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals.
Virus research - 1 Apr 1992
Tanaka T, Kato N, Nakagawa M, Ootsuyama Y, Cho M J, Nakazawa T, Hijikata M, Ishimura Y, Shimotohno K
Abstract excerpt
A hepatitis C virus (HCV) genome was isolated and sequenced from a single Japanese patient with chronic non-A, non-B hepatitis. The genome (HCV-JT), which was constructed with 23 cDNA clones, consisted of 9436 nucleotides with a long open reading frame which could encode a sequence of 3010 amino acid residues. To study the sequence variation of the HCV genome in an individual, we analyzed another sequence of the...
Topics
- Amino Acid Sequence
- Base Sequence
- Carrier State
- Cloning, Molecular
- DNA, Viral
- Genetic Variation
- Genome, Viral
- Hepacivirus
- Hepatitis C
- Humans
- Japan