Article
Altered homologous and heterologous gap-junctional intercellular communication in primary human liver tumors associated with aberrant protein localization but not gene mutation of connexin 32.
International journal of cancer - 2 Jan 1994
Krutovskikh V, Mazzoleni G, Mironov N, Omori Y, Aguelon A M, Mesnil M, Berger F, Partensky C, Yamasaki H
Abstract excerpt
Gap-junctional intercellular communication (GJIC) in 20 primary human liver tumors with different degrees of malignancy has been studied at the functional and molecular levels. When GJIC capacity was determined by dye-transfer assay performed directly with freshly removed tumor tissue, significant reduction was found in all samples, regardless of their morphology. In addition, a selective lack of GJIC between...
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