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Article

Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell-free conditions.

PloS one - 1 Jan 2013

Yanagimachi Masakatsu D, Niwa Akira, Tanaka Takayuki, Honda-Ozaki Fumiko, Nishimoto Seiko, Murata Yuuki, Yasumi Takahiro, Ito Jun, Tomida Shota, Oshima Koichi, Asaka Isao, Goto Hiroaki, Heike Toshio, Nakahata Tatsutoshi, Saito Megumu K

Abstract excerpt

Monocytic lineage cells (monocytes, macrophages and dendritic cells) play important roles in immune responses and are involved in various pathological conditions. The development of monocytic cells from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is of particular interest because it provides an unlimited cell source for clinical application and basic research on disease pathology....

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PMID: 23573196
DOI: 10.1371/journal.pone.0059243
PMCID: PMC3616072

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