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Article

Independent Evolution of HIV Type 1 in Different Brain Regions

10 Jun 1999

Abstract excerpt

HIV-1-associated brain pathology exhibits regional variability and we therefore studied the genetic differences in the V1-V5 domains of the HIV env gene in up to four regions of brain (frontal lobe, basal ganglia, medial temporal lobe, and nonmedial temporal lobe) from three patients. We found that in each separate brain region HIV-1 forms different quasispecies and that there is little gene flow among these...

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PMID: 10381169
DOI: 10.1089/088922299310719

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