Article
High resolution analysis of HIV-1 quasispecies in the brain.
AIDS (London, England) - 1 Apr 1995
Monken C E, Wu B, Srinivasan A
Abstract excerpt
OBJECTIVE: To characterize HIV-1 quasispecies at high resolution to determine the in vivo sequence heterogeneity of virus infecting the brain. METHODS: A 1 kilobase region of the envelope gene, which includes the five hypervariable regions, was amplified by polymerase chain reaction (PCR) using D...
Topics
- AIDS Dementia Complex
- Amino Acid Sequence
- Base Sequence
- Brain
- Cloning, Molecular
- DNA Primers
- DNA, Viral
- Genes, env
- Genetic Variation
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Proviruses
- Sequence Homology, Amino Acid