Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 1 Mar 2007

Peters Paul J, Dueñas-Decamp Maria J, Sullivan W Matthew, Clapham Paul R

Abstract excerpt

Human immunodeficiency virus (HIV)-positive individuals frequently suffer from progressive encephelopathy, which is characterized by sensory neuropathy, sensory myelopathy, and dementia. Our group and others have reported the presence of highly macrophage-tropic R5 variants of HIV-1 in brain tiss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Dementia Complex
Share to Brain
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to Macrophages

Share to Organ Specificity

Share to Receptors, CCR5

Share to Tropism

Source

Identifiers

PMID: 18040824
DOI: 10.1007/s11481-006-9042-2

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18040824-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues.PMID 18040824Read ↗

Non-Macrophage-Tropic Human Immunodeficiency Virus Type 1 R5 Envelopes Predominate in Blood, Lymph Nodes, and Semen: Implications for Transmission and PathogenesisSemantic proximity Read ↗

Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages.Semantic proximity Read ↗

Phenotypic Correlates of HIV-1 Macrophage TropismSemantic proximity Read ↗

Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissueSemantic proximity Read ↗

Viral Determinants of HIV-1 Macrophage TropismSemantic proximity Read ↗

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the BrainSemantic proximity Read ↗

HIV-1 replication in the central nervous system occurs in two distinct cell types.Semantic proximity Read ↗

Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques.Semantic proximity Read ↗

Determinants Flanking the CD4 Binding Loop Modulate Macrophage Tropism of Human Immunodeficiency Virus Type 1 R5 EnvelopesSemantic proximity Read ↗

Evolution driven by a varying host environment selects for distinct HIV-1 entry phenotypes and other informative variantsSemantic proximity Read ↗

Chemokine Receptor Utilization by Human Immunodeficiency Virus Type 1 Isolates That Replicate in MicrogliaSemantic proximity Read ↗

HIV-1 envelope–receptor interactions required for macrophage infection and implications for current HIV-1 cure strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.