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Article

HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease.

Journal of acquired immune deficiency syndromes - 1 Jan 1991

Pang S, Vinters H V, Akashi T, O'Brien W A, Chen I S

Abstract excerpt

We investigated sequence variation in the human immunodeficiency virus type 1 (HIV-1) env gene region that encodes the fourth disulfide-bonded domain of the external membrane glycoprotein, gp120, among three HIV-1 isolates from patients with AIDS-related neurologic disease. The sequences of HIV-1 isolated directly from brain tissue, blood cells, and in vitro cell cultures were compared. The results suggest that...

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PMID: 1684385

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