HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease.

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Article

HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease.

Journal of acquired immune deficiency syndromes - 1 Jan 1991

Pang S, Vinters H V, Akashi T, O'Brien W A, Chen I S

Abstract excerpt

We investigated sequence variation in the human immunodeficiency virus type 1 (HIV-1) env gene region that encodes the fourth disulfide-bonded domain of the external membrane glycoprotein, gp120, among three HIV-1 isolates from patients with AIDS-related neurologic disease. The sequences of HIV-1 isolated directly from brain tissue, blood cells, and in vitro cell cultures were compared. The results suggest that...

Topics

AIDS Dementia Complex
Adult
Aged
Amino Acid Sequence
Base Sequence
Brain
Brain Chemistry
CD4 Antigens
CD4-Positive T-Lymphocytes
Female
Genes, env

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV-1

Humans

Immunoglobulin Variable Region

Male

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1684385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1684385-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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