Article
Low levels of p53 are associated with resistance to tetrachlorodibenzo-p-dioxin toxicity in DBA/2 mice.
Pharmacogenetics - 1 Apr 1999
Yang A L, Smith A G, Akhtar R, Clothier B, Robinson S, MacFarlane M, Festing M F
Abstract excerpt
We show here that DBA/2 strain mice have a complex mutation/polymorphism in the promoter region of the Trp53 locus (the mouse p53 locus). This region has previously been shown to be essential for p53 expression. We further show that the DBA/2 mutation is associated with approximately fourfold lower p53 levels in thymocytes treated with the DNA-damaging agent etoposide in-vitro, and with relative resistance of...
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