Article
Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides.
Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2007
Du Liutao, Pollard Julianne M, Gatti Richard A
Abstract excerpt
We used antisense morpholino oligonucleotides (AMOs) to redirect and restore normal splicing of three prototypic splicing mutations in the ataxia-telangiectasia mutated (ATM) gene. Two of the mutations activated cryptic 5' or 3' splice sites within exonic regions; the third mutation activated a downstream 5' splice site leading to pseudoexon inclusion of a portion of intron 28. AMOs were targeted to aberrant...
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