Article
Role of dimerization of the membrane-associated growth factor kit ligand in juxtacrine signaling: the Sl17H mutation affects dimerization and stability-phenotypes in hematopoiesis.
The Journal of experimental medicine - 4 May 1998
Tajima Y, Huang E J, Vosseller K, Ono M, Moore M A, Besmer P
Abstract excerpt
The Kit ligand (KL)/Kit receptor pair functions in hematopoiesis, gametogenesis, and melanogenesis. KL is encoded at the murine steel (Sl) locus and encodes a membrane growth factor which may be proteolytically processed to produce soluble KL. The membrane-associated form of KL is critical in med...
Topics
- Amino Acid Sequence
- Animals
- Bone Marrow Cells
- COS Cells
- Dimerization
- Flow Cytometry
- Hematopoiesis
- Humans
- Mast Cells
- Mice
- Microscopy, Fluorescence
- Molecular Sequence Data
- Mutation
- RNA Splicing