Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection.

doi:10.1086/315187

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Article

Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection.

The Journal of infectious diseases - 1 Jan 2000

Carl S, Daniels R, Iafrate A J, Easterbrook P, Greenough T C, Skowronski J, Kirchhoff F

Abstract excerpt

A 36-bp deletion close to the 5' end of NEF that impaired Nef function was found in a long-term nonprogressor with human immunodeficiency virus type 1 (HIV-1) infection. Forms containing an adjacent duplication of 33 bp were also frequently observed. The duplication showed no homology to the deleted region but restored the overall length of the first variable loop of Nef. NEF alleles carrying the duplication were...

Topics

Adult
Alleles
Amino Acid Sequence
Case-Control Studies
DNA Repair
Gene Duplication
Gene Products, nef
Genes, nef
HIV Infections
HIV Long-Term Survivors
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Antigens Class I

Homosexuality

Humans

London

Male

Molecular Sequence Data

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 10608759
DOI: 10.1086/315187

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