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LD78β, A Non-allelic Variant of Human MIP-1α (LD78α), Has Enhanced Receptor Interactions and Potent HIV Suppressive Activity

1 Jun 1999

Abstract excerpt

Chemokines play diverse roles in inflammatory and non-inflammatory situations via activation of heptahelical G-protein-coupled receptors. Also, many chemokine receptors can act as cofactors for cellular entry of human immunodeficiency virus (HIV) in vitro. CCR5, a receptor for chemokines MIP-1alpha (LD78alpha), MIP-1beta, RANTES, and MCP2, is of particular importance in vivo as polymorphisms in this gene affect...

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PMID: 10364178
DOI: 10.1074/jbc.274.25.17478

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