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Article

Chemokines and chemokine receptors in HIV infection: role in pathogenesis and therapeutics.

Journal of postgraduate medicine - 1 Jan 2000

Suresh P, Wanchu A

Abstract excerpt

Chemokines are known to function as regulatory molecules in leukocyte maturation, traffic, homing of lymphocytes and in the development of lymphoid tissues. Besides these functions in the immune system, certain chemokines and their receptors are involved in HIV pathogenesis. In order to infect a target cell, the HIV envelope glycoprotein gp120 has to interact with the cellular receptor CD-4 and co-receptor, CC or...

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PMID: 16855325

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