Article
Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor. Evidence that Glu19 of G-CSF interacts with Arg288 of the receptor.
The Journal of biological chemistry - 18 Jun 1999
Layton J E, Shimamoto G, Osslund T, Hammacher A, Smith D K, Treutlein H R, Boone T
Abstract excerpt
Granulocyte colony-stimulating factor (G-CSF) forms a tetrameric complex with its receptor, comprising two G-CSF and two receptor molecules. The structure of the complex is unknown, and it is unclear whether there are one or two binding sites on G-CSF and the receptor. The immunoglobulin-like dom...
Topics
- Antigens, CD
- Arginine
- Binding Sites
- Cell Division
- Cell Line
- Cytokine Receptor gp130
- Dimerization
- Flow Cytometry
- Glutamic Acid
- Granulocyte Colony-Stimulating Factor
- Humans