Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.

The Biochemical journal - 15 Aug 2011

Lambert Que T, Pradhan Anuradha, Roll J Devon, Reuther Gary W

Abstract excerpt

Cytokines and their receptors regulate haemopoiesis by controlling cellular growth, survival and differentiation. Thus it is not surprising that mutations of cytokine receptors contribute to the formation of haemopoietic disorders, including cancer. We recently identified transforming properties of IL27R, the ligand-binding component of the receptor for interleukin-27. Although wild-type IL27R exhibits...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to Fusion Proteins, bcr-abl
Share to Janus Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Myeloid Cells

Share to Receptors, Cytokine

Share to Receptors, Interleukin

Share to STAT Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21631431
DOI: 10.1042/BJ20110351
PMCID: PMC3145822

Genes

BCR
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.PMID 21631431Read ↗

Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptorSemantic proximity Read ↗

The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy.Semantic proximity Read ↗

Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27Semantic proximity Read ↗

Deleterious and Oncogenic Mutations in the IL7RASemantic proximity Read ↗

Structural Rewiring of IL-7R Dimerization by an Oncogenic Transmembrane Mutation Can Be Reversed by Rational DesignSemantic proximity Read ↗

Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design.Semantic proximity Read ↗

Activating mutations in cytokine receptors: implications for receptor function and role in disease.Semantic proximity Read ↗

Activation of JAK2-V617F by components of heterodimeric cytokine receptors.Semantic proximity Read ↗

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.Semantic proximity Read ↗

Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors.Semantic proximity Read ↗

Signaling from the IL-2 receptor to the nucleus.Semantic proximity Read ↗

Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.