Article
Advances in understanding postreceptor signaling in response to granulocyte colony-stimulating factor.
Current opinion in hematology - 1 May 1997
Tidow N, Welte K
Abstract excerpt
Granulocyte colony-stimulating factor (G-CSF) exerts its biologic effects through binding to its receptor expressed on myeloid cells. Like other cytokines, G-CSF induces intracellular protein tyrosine phosphorylation and activates various signaling cascades. Activation of JAK tyrosine kinases and signal transducers and activators of transcription (STAT) proteins as well as activation of the ras-MAP kinase route...
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