Advances in understanding postreceptor signaling in response to granulocyte colony-stimulating factor.

doi:10.1097/00062752-199704030-00003

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Article

Advances in understanding postreceptor signaling in response to granulocyte colony-stimulating factor.

Current opinion in hematology - 1 May 1997

Tidow N, Welte K

Abstract excerpt

Granulocyte colony-stimulating factor (G-CSF) exerts its biologic effects through binding to its receptor expressed on myeloid cells. Like other cytokines, G-CSF induces intracellular protein tyrosine phosphorylation and activates various signaling cascades. Activation of JAK tyrosine kinases and...

Topics

Granulocyte Colony-Stimulating Factor
Humans
Mutation
Receptors, Granulocyte Colony-Stimulating Factor
Signal Transduction
Structure-Activity Relationship

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