Article
Colorectal adenoma and cancer divergence. Evidence of multilineage progression.
The American journal of pathology - 1 Jun 1999
Tsao J L, Tavaré S, Salovaara R, Jass J R, Aaltonen L A, Shibata D
Abstract excerpt
Colorectal cancer progression involves changes in phenotype and genotype. Although usually illustrated as a linear process, more complex underlying pathways have not been excluded. The object of this paper is to apply modern quantitative principles of molecular evolution to multistep tumor progression. To reconstruct progression lineages, the genotypes of two adjacent adenoma-cancer pairs were determined by...
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