Article
A genetic basis for the multi-step pathway of colorectal tumorigenesis.
Princess Takamatsu symposia - 1 Jan 1991
Fearon E R
Abstract excerpt
Colorectal tumors provide an excellent system in which to search for and study the genetic alterations involved in the development of a common human cancer. Data from many clinical and histopathological studies suggest that most carcinomas arise from preexisting adenomas. In addition, colorectal tumors of various stages of development can be obtained for studies of genetic alterations, unlike the situation in...
Topics
- Adenomatous Polyposis Coli
- Base Sequence
- Colorectal Neoplasms
- Gene Deletion
- Genes, DCC
- Genes, Tumor Suppressor
- Genes, p53
- Genes, ras
- Humans
- Models, Genetic
- Molecular Sequence Data
- Mutation