Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions

1 Jun 1999

Abstract excerpt

Structural changes in the androgen receptor (AR) are one of the causes of defective spermatogenesis. We screened the AR gene of 173 infertile men with impaired spermatogenesis and identified 3 of them, unrelated, who each had a single adenine-->guanine transition that changed codon 886 in exon 8 from methionine to valine. This mutation was significantly associated with the severely oligospermic phenotype and was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Hormonal and reproductive studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Sexual Differentiation and Disorders

Source

Identifiers

PMID: 10359561
DOI: 10.1172/jci4289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactionsPMID 10359561Read ↗

Human androgen receptor mutation disrupts ternary interactions between ligand, receptor domains, and the coactivator TIF2 (transcription intermediary factor 2).Semantic proximity Read ↗

Androgen receptor polymorphisms and mutations in male infertility.Semantic proximity Read ↗

Analysis of the transactivation domain of the androgen receptor in patients with male infertility.Semantic proximity Read ↗

Azoospermia associated with a mutation in the ligand-binding domain of an androgen receptor displaying normal ligand binding, but defective trans-activation.Semantic proximity Read ↗

Molecular basis of androgen receptor diseases.Semantic proximity Read ↗

Significance of Mutations in the Androgen Receptor Gene in Males with Idiopathic Infertility1Semantic proximity Read ↗

Genetics of male infertility: role of androgen receptor mutations and Y-microdeletions.Semantic proximity Read ↗

Male infertility and androgen receptor gene mutations: clinical features and identification of seven novel mutations.Semantic proximity Read ↗

Androgen receptor abnormalities.Semantic proximity Read ↗

Molecular defects of the androgen receptor.Semantic proximity Read ↗

Disrupted Amino- and Carboxyl-Terminal Interactions of the Androgen Receptor Are Linked to Androgen InsensitivitySemantic proximity Read ↗

Molecular pathology of the androgen receptor in male (in)fertility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.